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Published on: January 28, 2020
Novel inflammatory biomarkers in the prognosis of COVID-19
Kegang Zhan1,2, Luhan Wang1, Hao Lin3
1Department of Epidemiology, College of Preventive Medicine, Third Military Medical University (Army Medical University), Chongqing, China.
Insights
Novel inflammatory biomarkers like endocan and MDW are elevated in COVID-19 patients and can predict poor prognosis and death. These findings aid in understanding COVID-19 progression and patient outcomes.
Area of Science:
- Immunology
- Infectious Diseases
- Biomarker Discovery
Background:
- Inflammatory progression is central to COVID-19 severity.
- The prognostic role of novel inflammatory biomarkers in COVID-19 is debated.
Conclusions:
- This meta-analysis offers comprehensive evidence on novel inflammatory biomarkers in COVID-19 prognosis.
- Biomarkers demonstrate significant discriminatory ability for predicting death and poor outcomes.
- Findings support the use of these biomarkers for enhanced COVID-19 patient evaluation.
Background:
The central role of inflammatory progression in the development of Coronavirus disease 2019 (COVID-19), especially in severe cases, is indisputable. However, the role of some novel inflammatory biomarkers in the prognosis of COVID-19 remains controversial.
Objective:
To assess the effect of some novel inflammatory biomarkers in the occurrence and prognosis of COVID-19.
Methods:
We systematically retrieved the studies related to COVID-19 and the inflammatory biomarkers of interest. The data of each biomarker in different groups were extracted, then were categorized and pooled. The standardized mean difference was chosen as an effect size measure to compare the difference between groups.
Results:
A total of 90 studies with 12,059 participants were included in this study. We found higher levels of endocan, PTX3, suPAR, sRAGE, galectin-3, and monocyte distribution width (MDW) in the COVID-19 positive groups compared to the COVID-19 negative groups. No significant differences for suPAR and galectin-3 were detected between the severe group and mild/moderate group of COVID-19. In addition, the deaths usually had higher levels of PTX3, sCD14-ST, suPAR, and MDW at admission compared to the survivors. Furthermore, patients with higher levels of endocan, galectin-3, sCD14-ST, suPAR, and MDW usually developed poorer comprehensive clinical prognoses.
Conclusions:
In summary, this meta-analysis provides the most up-to-date and comprehensive evidence for the role of the mentioned novel inflammatory biomarkers in the prognosis of COVID-19, especially in evaluating death and other poor prognoses, with most biomarkers showing a better discriminatory ability.
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