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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Left atrial function index predicts poor outcomes in acute myocardial infarction patients treated with percutaneous

Yijin Tang1, Siling Peng1, Hui-Ling Yao2

  • 1Department of Cardiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, China.

Frontiers in Cardiovascular Medicine
|September 20, 2023
PubMed

Insights

The left atrial function index (LAFI) can predict adverse events in acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI). Lower LAFI values indicate a higher risk of adverse cardiovascular events, aiding in patient risk stratification.

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiovascular Research

Background:

  • The prognostic significance of the left atrial function index (LAFI) in acute myocardial infarction (AMI) patients treated with percutaneous coronary intervention (PCI) remains unclear.
  • LAFI integrates left atrial emptying fraction, adjusted left atrial volume, and stroke volume.

Purpose of the Study:

  • To investigate the predictive value of LAFI for prognosis in patients with AMI who have undergone PCI.
  • To determine if LAFI can be utilized for risk stratification in this patient population.

Main Methods:

  • Prospective enrollment of 368 AMI patients treated with PCI.
  • Transthoracic echocardiography (TTE) performed at baseline and follow-up.
  • Endpoint events included rehospitalization for unstable angina, nonfatal myocardial infarction, heart failure, and cardiovascular death.

Main Results:

  • Patients experiencing endpoint events had significantly lower LAFI compared to those without events (34.25 ± 12.86 vs. 48.38 ± 19.42, P < 0.0001).
  • Multivariate Cox analysis identified LAFI (HR=0.97; P=0.012) and Killip classification (HR=1.51; P=0.034) as independent predictors of adverse events.
  • Kaplan-Meier analysis showed significantly higher event rates in patients with LAFI ≤ 40.17 cm/ml/m² (HR=8.53; P < 0.0001).

Conclusions:

  • The left atrial function index (LAFI) is a robust and independent predictor of adverse cardiovascular events in AMI patients treated with PCI.
  • LAFI can be effectively used for risk stratification in this patient cohort, guiding clinical management.
Abstract

Keywords:
acute myocardial infarctionleft atrial function indexpercutaneous coronary interventionprognosistransthoracic echocardiography

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