Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dissolution profiles in column dissolution.

J T Carstensen, Y Yonezawa

    Journal of Pharmaceutical Sciences
    |August 1, 1986
    PubMed
    Summary

    A new model describes column dissolution, showing an inverse sigmoid profile for particle concentration over time. This model accurately predicts experimental dissolution data, validating its approach.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Relationship between the combination of polyunsaturated fatty acids intake and psychological distress during pregnancy: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.

    Prostaglandins, leukotrienes, and essential fatty acids·2022
    Same author

    A Novel IFITM5 Variant Associated with Phenotype of Osteoporosis with Calvarial Doughnut Lesions: A Case Report.

    Calcified tissue international·2021
    Same author

    Copy number loss in the region of the <i>ASPN</i> gene in patients with acetabular dysplasia: <i>ASPN</i> CNV in acetabular dysplasia.

    Bone & joint research·2017
    Same author

    Biotransformation of halogenated benzenes in anaerobic sediments.

    Environmental science and pollution research international·2013
    Same author

    A resonating broken symmetry configuration interaction approach for double-exchange magnetic systems.

    Journal of physics. Condensed matter : an Institute of Physics journal·2011
    Same author

    High-sensitivity two-dimensional thermal- and mechanical-stress-induced birefringence measurements in a Nd:YAG rod.

    Applied optics·2010

    Area of Science:

    • Chemical Engineering
    • Physical Chemistry

    Background:

    • Understanding particulate dissolution is crucial for various industrial processes.
    • Existing models may not fully capture the dynamics of open-ended column dissolution.

    Purpose of the Study:

    • To present a self-consistent model for open-ended column dissolution.
    • To analyze the concentration profile of the efflux stream over time.

    Main Methods:

    • Developed a model based on plug flow with a defined residence time.
    • Assumed isometric particles adhering to Levich-type particulate dissolution.
    • Utilized the plug flow parameter (Q2) for model validation.

    Main Results:

    • The model predicts an inverse sigmoid profile for efflux concentration versus time.
    • Demonstrated consistency between the plug flow parameter and experimental data.
    • Achieved good correlation between predicted and experimental dissolution profiles.

    Conclusions:

    • The presented model accurately describes open-ended column dissolution.
    • The inverse sigmoid profile is a characteristic outcome of this dissolution process.
    • The model provides a reliable framework for predicting particulate dissolution behavior.

    Related Experiment Videos