Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

16
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
16
Electrocardiogram01:29

Electrocardiogram

2.4K
An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hounsfield unit measurements from different regions of interest in lumbar spine CT: correlation with DEXA-derived bone mineral density and fracture status.

BMC musculoskeletal disorders·2026
Same author

MANF safeguards mitochondria-associated endoplasmic reticulum membrane integrity in nucleus pulposus-derived mesenchymal stem cells to maintain homeostasis of the intervertebral disc.

Cell biology and toxicology·2026
Same author

The Treatment Efficacy for Patients Undergoing Combined Transanal-Transabdominal Endoscopic Resection of Rectal Anastomosis Stenosis.

Journal of surgical oncology·2026
Same author

Neoadjuvant toripalimab plus celecoxib versus toripalimab monotherapy for mismatch repair-deficient or microsatellite instability-high, locally advanced colorectal cancer (PICC-2): an open-label, multicentre, randomised, phase 2 trial.

The Lancet. Oncology·2026
Same author

Assembly and Comparative Analysis of the Complete Mitochondrial Genome of <i>Corydalis ophiocarpa</i> (Papaveraceae).

Current issues in molecular biology·2026
Same author

Which vertebral levels provide practical HU-based assessment for osteoporosis screening? A comparative analysis from T1 to S2.

Journal of orthopaedic surgery and research·2026

Related Experiment Video

Updated: Jul 16, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.5K

Predicting apical hypertrophic cardiomyopathy using T-wave inversion: Three case reports.

Liang Kang1, Yi-Hua Li1, Rong Li2

  • 1The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China.

World Journal of Clinical Cases
|September 20, 2023
PubMed
Summary

Giant negative T waves (GNTs) on ECG may predict apical hypertrophic cardiomyopathy (AHCM) years before structural changes appear. This finding highlights the early diagnostic value of electrocardiograms for AHCM.

Keywords:
Apical hypertrophic cardiomyopathyCase reportEchocardiographyElectrocardiogramHypertrophic cardiomyopathyNegative T waves

More Related Videos

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

684
Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations
12:09

Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations

Published on: January 8, 2013

13.7K

Related Experiment Videos

Last Updated: Jul 16, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.5K
Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System
10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

684
Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations
12:09

Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations

Published on: January 8, 2013

13.7K

Area of Science:

  • Cardiology
  • Medical Diagnostics
  • Electrophysiology

Background:

  • Apical hypertrophic cardiomyopathy (AHCM) is a distinct form of hypertrophic cardiomyopathy.
  • Left ventricular apical hypertrophy in AHCM can be subtle and challenging to detect via echocardiography.
  • Giant negative T waves (GNTs) in precordial leads are characteristic electrocardiogram (ECG) findings in AHCM.

Observation:

  • Three patients (68F, 59M, 55F) presented with prolonged chest symptoms (chest tightness, chest pain).
  • All patients exhibited GNTs on ECG, observed years before the development of apical hypertrophy.
  • Other potential causes for T-wave inversion were excluded in these cases.

Findings:

  • Electrophysiological abnormalities, specifically GNTs, manifest earlier than the structural changes (apical hypertrophy) in AHCM.
  • ECG findings precede the echocardiographic diagnosis of AHCM by several years in these cases.

Implications:

  • ECG, particularly the presence of GNTs, holds significant predictive value for early AHCM detection.
  • This suggests a potential role for routine ECG screening in identifying individuals at risk for AHCM.
  • Earlier diagnosis of AHCM through ECG can facilitate timely intervention and management.