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IL-32 as a potential biomarker and therapeutic target in skin inflammation
Alexandra Wallimann1, Mirjam Schenk1,2
1Christine Kühne - Center for Allergy Research and Education (CK-CARE), Davos, Switzerland.
Abstract:
IL-32 is a recently described cytokine that performs a variety of functions under inflammatory conditions. Serum IL-32 has been shown to be elevated in several diseases, including type 2 diabetes, cancer, systemic lupus erythematosus, HIV infection, and atopic diseases including atopic dermatitis. There are nine different isoforms of IL-32, with IL-32γ being the most biologically active one. The following review summarizes the different roles of the various IL-32 isoforms in the context of skin inflammation, with a focus on atopic dermatitis.
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