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Updated: Jul 16, 2025
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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
Published on: April 8, 2016
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Cellular Mechanisms of Psoriasis Pathogenesis: A Systemic Review
Mengjun Wu1, Chan Dai2, Fanfan Zeng3
1Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Clinical, Cosmetic and Investigational Dermatology
|September 20, 2023
Summary
This review systematically examines the roles of various cells in psoriasis pathogenesis. Understanding these cellular interactions is crucial for developing more effective psoriasis treatments beyond current cytokine-targeting therapies.
Area of Science:
- Dermatology
- Immunology
- Cell Biology
Background:
- Psoriasis is a common inflammatory skin disease driven by abnormal keratinocyte proliferation and inflammatory cell infiltration.
- Key cells implicated include keratinocytes, T lymphocytes, dendritic cells, neutrophils, and macrophages.
- Existing treatments targeting cytokines like IL-23, IL-17A, and TNF-α offer symptom relief but not a cure and can have adverse effects.
Purpose of the Study:
- To systematically review the roles of diverse cell types in psoriasis pathogenesis.
- To provide a deeper understanding of cellular and molecular mechanisms underlying psoriasis development.
- To offer new perspectives for the development of novel psoriasis therapeutic strategies.
Main Methods:
- Comprehensive literature review of studies investigating cellular involvement in psoriasis.
- Analysis of the contribution of keratinocytes, immune cells, and other cell types to disease progression.
- Synthesis of current knowledge on cellular and molecular pathways in psoriasis.
Main Results:
- Detailed summary of the specific functions and interactions of keratinocytes, T cells, dendritic cells, neutrophils, and macrophages in psoriasis.
- Identification of critical cellular pathways contributing to epidermal hyperplasia and inflammation.
- Highlighting the limitations of current targeted therapies and the need for alternative approaches.
Conclusions:
- A comprehensive understanding of cellular roles in psoriasis is essential for advancing treatment.
- Further research into cellular mechanisms may uncover new therapeutic targets.
- This review provides a foundation for developing more effective and potentially curative psoriasis treatments.
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