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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

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Failure Patterns Within Different Histological Types in Sinonasal Malignancies: Making the Complex Simple.

Qian Liu¹, Meng Sun¹, Zekun Wang¹

¹Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery

|September 20, 2023

Summary

Adenoid cystic carcinoma (ACC) shows moderate risks for local recurrence and distant metastasis. Other sinonasal malignancies like squamous cell carcinoma (SCC) and mucosal melanoma (MM) present higher risks for these failures.

Keywords:

distant metastasis failure pattern histological subtypes local recurrence sinonasal malignancies

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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

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Published on: January 5, 2017

Area of Science:

Oncology
Head and Neck Surgery
Pathology

Background:

Sinonasal malignancies (SNMs) encompass a diverse group of rare cancers.
Understanding failure patterns is crucial for optimizing treatment strategies.
Histological subtype significantly influences prognosis and treatment outcomes in SNMs.

Purpose of the Study:

To investigate and compare failure patterns across various histological subtypes of sinonasal malignancies.
To identify specific subtypes with higher risks of local recurrence and distant metastasis.

Main Methods:

Retrospective analysis of patient data from an academic university hospital.
Inclusion of 897 patients diagnosed with SNMs between 1999 and 2019.
Assessment of failure patterns, including local recurrence (LR) and distant metastasis (DM), stratified by histological subtype.

Main Results:

Adenoid cystic carcinoma (ACC) demonstrated moderate risks for both LR and DM.
Squamous cell carcinoma (SCC), adenocarcinoma (AC), soft tissue sarcoma (STS), and mucosal melanoma (MM) were associated with a high risk of LR.
Neuroendocrine carcinoma (NEC), STS, and MM were identified as high-risk groups for DM.

Conclusions:

ACC exhibits intermediate risks for local and distant failures.
SCC, AC, STS, and MM are associated with elevated risks of local recurrence.
NEC, STS, and MM carry a high risk of distant metastasis, necessitating close monitoring and tailored management.