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Updated: Jul 16, 2025
07:25
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
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Analysis of Lower Extremity Amputations from the SerbVasc Registry
Slobodan Tanaskovic1,2, Nenad Ilijevski1,2, Igor Koncar2,3
1Vascular Surgery Clinic, "Dedinje" Cardiovascular Institute, Belgrade, Serbia.
Summary
Peripheral arterial disease (PAD) and diabetes lead to high lower extremity amputation (LEA) mortality. Early PAD diagnosis and treatment are crucial to reduce amputations and deaths.
Area of Science:
- Vascular Surgery
- Diabetology
- Public Health
Background:
- Peripheral arterial disease (PAD) and diabetes are primary drivers of lower extremity amputations (LEAs) globally.
- High morbidity and mortality rates associated with LEAs impose a significant burden on healthcare systems.
Purpose of the Study:
- To report overall morbidity and mortality rates following major and minor LEAs.
- To analyze predictive factors influencing adverse outcomes in patients with LEAs.
Main Methods:
- Utilized data from the Serbian Vascular Registry (SerbVasc) from January 2020 to December 2022.
- Analyzed 702 patients with LEAs, examining diabetes prevalence, prior revascularization, infection, tissue loss, and mortality predictors.
Main Results:
- Overall mortality rate was 6.9%, with intrahospital mortality of 11.1% for above-the-knee amputations.
- Key mortality predictors included age >65, chronic kidney disease, ischemic heart disease, emergency admission, and postoperative complications.
- Only 20.3% of patients had prior peripheral revascularization.
Conclusions:
- High mortality after LEAs highlights the need for improved early diagnosis and timely treatment of PAD.
- A low rate of prior revascularization underscores the importance of proactive PAD management to prevent amputations.
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