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COVID-19 is more lethal in hemodialysis chronic kidney disease patients with low physical capacity

Rafael B Orcy1,2, Caroline C Bluhm1, Larissa R Ribeiro3

  • 1Postgraduate Programme in Physical Education, Federal University of Pelotas, Pelotas, Brazil.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|September 20, 2023
PubMed

Insights

Patients on maintenance hemodialysis with lower functional capacity experienced higher COVID-19 mortality. Poorer physical performance in these patients correlated with worse outcomes during the pandemic.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Public Health

Background:

  • Maintenance hemodialysis (HD) patients face high mortality rates.
  • Low functional capacity (FC) is a known risk factor in HD patients.
  • The impact of FC on COVID-19 lethality in HD patients requires investigation.

Purpose of the Study:

  • To analyze the association between functional capacity (FC) and COVID-19 lethality in patients undergoing maintenance hemodialysis (HD).

Main Methods:

  • A cohort study involving FC evaluations in HD patients.
  • COVID-19 lethality was assessed as an ad-hoc outcome.
  • Physical performance tests included the six-minutes-walking-test (6MWT), 30-second sit-to-stand test (30CST), and timed up and go test (TUG).

Main Results:

  • Out of 112 HD patients, 31 contracted symptomatic COVID-19, with 11 deaths (35.5% lethality rate).
  • Non-survivors showed significantly poorer performance in 6MWT, 30CST, and TUG compared to survivors.
  • A significant association was found between reduced percentages of predicted 6MWT, 30CST, and TUG scores and COVID-19 lethality.

Conclusions:

  • Poorer physical functional capacity is linked to worse COVID-19 prognosis in patients on maintenance hemodialysis.
  • Functional capacity assessments can help identify HD patients at higher risk for severe COVID-19 outcomes.
Abstract

Keywords:
COVID-19functional capacityhemodialysis patients

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