Related Experiment Video

Updated: Jul 16, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
06:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.8K

Assessment of fibroblast growth factor 21 in children with type 1 diabetes mellitus in relation to microvascular

Nermien Tantawy1, Eman Sherif1, Randa M Matter1

  • 1Paediatrics Department, Paediatric and Adolescent Diabetes Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Pediatric Endocrinology, Diabetes, and Metabolism
|September 20, 2023
PubMed

Insights

Fibroblast growth factor 21 (FGF21) levels are significantly elevated in children with type 1 diabetes mellitus (DM1) compared to healthy controls. Higher FGF21 correlates with longer diabetes duration and poorer glycemic control, but not microvascular complications.

Area of Science:

  • Endocrinology
  • Metabolic Regulation
  • Pediatric Health

Background:

  • Type 1 diabetes mellitus (DM1) is a growing global health concern.
  • Fibroblast growth factor 21 (FGF21), a liver-expressed adipokine, is crucial in metabolic regulation.

Purpose of the Study:

  • To compare FGF21 levels in children with DM1 versus controls.
  • To investigate correlations between FGF21 and diabetes duration, HbA1c, and microvascular complications.

Main Methods:

  • Study included 50 children with DM1 (ages 5-16) and 50 healthy controls.
  • Assessed FGF21 levels, diabetes duration, HbA1c, urinary albumin creatinine ratio (UACR), and fundus examination.

Main Results:

  • FGF21 levels were significantly higher in children with DM1 (median 150 pg/ml) than controls (median 35 pg/ml) (p < 0.001).
  • FGF21 positively correlated with diabetes duration (p < 0.001), mean blood glucose (p = 0.015), and HbA1c (p = 0.018).
  • No significant FGF21 elevation was observed in DM1 patients with diabetic nephropathy or retinopathy (p = 0.122, p = 0.298).

Conclusions:

  • FGF21 is significantly elevated in children with DM1.
  • The role of FGF21 in diabetic microvascular complications requires further investigation.
Abstract

Keywords:
childrentype 1 diabetes mellitusFGF21

More Related Videos

Non-invasive Assessment of Microvascular and Endothelial Function05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

16.3K
Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tgfli:EGFP Zebrafish Retinal Vasculature10:07

Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tgfli:EGFP Zebrafish Retinal Vasculature

Published on: December 26, 2017

13.3K

Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.7K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.5K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
980
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
581
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
309