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Premature pubarche during minipuberty - literature review and two case reports
Anna Rakuś-Kwiatosz1,2, Elżbieta Budzyńska1, Iwona Beń-Skowronek1
1Department of Pediatric Endocrinology and Diabetology, Medical University of Lublin, Poland.
Insights
Isolated pubic hair in infancy, a variant of precocious puberty, requires careful diagnosis. This mild condition is self-limiting but needs monitoring to rule out serious causes.
Area of Science:
- Pediatric Endocrinology
- Reproductive Medicine
Background:
- Premature pubarche (PP) in infancy presents diagnostic challenges due to low incidence and variable hormone levels.
- Lack of standardized laboratory criteria complicates the diagnosis of PP.
Observation:
- This review examines literature and presents two cases of male infants with pubic hair during minipuberty.
- Isolated pubic hair in infancy necessitates differential diagnosis to exclude serious underlying conditions.
Findings:
- Isolated pubic hair in infancy is likely a mild, self-limiting form of precocious puberty.
- The condition may result from heightened hair follicle sensitivity to transient androgen increases during minipuberty.
Implications:
- Isolated pubic hair in infancy should be considered a diagnosis of exclusion.
- While typically resolving spontaneously, continued follow-up is crucial to monitor for any progression indicative of a more serious etiology.
Introduction:
Isolated premature pubarche (PP) in infancy may be the reason for many diagnostic difficulties. This is due to the low incidence and, therefore, the limited number of studies on this subject and the lack of strict laboratory standards because of the physiological variability of gonadotropic hormone and androgen concentrations during minipuberty.
Material And Methods:
We aimed to present current knowledge about PP in infancy based on the literature review and 2 cases of male infants with scrotal hair during minipuberty.
Results:
Isolated hair in the pubic region in a boy during the period of minipuberty requires differential diagnosis. After excluding serious aetiology, it seems to be a mild, self-limiting variant of precocious puberty. The phenomenon is probably a result of increased sensitivity of the hair follicles to transiently increased androgen concentration.
Conclusions:
Isolated pubic hair in infancy as a mild, self-limiting variant of precocious puberty in infants should be a diagnosis of exclusion. The condition resolves spontaneously, but it absolutely requires further follow-up to exclude serious aetiology in the case of puberty progression.
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