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Updated: Jul 16, 2025
09:16
Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
17.7K
[General recommendations for the management of glomerular diseases-2023]
Martin Windpessl1,2, Philipp Gauckler3, Emanuel Zitt4
1Medizinische Fakultät, JKU, Linz, Österreich.
Wiener Klinische Wochenschrift
|September 20, 2023
Summary
Glomerular diseases can cause serious complications like infections and blood clots. This review details immunosuppressants, focusing on rituximab and cyclophosphamide, and offers prevention strategies for nephrotic patients.
Area of Science:
- Nephrology
- Immunology
- Pharmacology
Context:
- Glomerular diseases present significant extrarenal complications, including thromboembolism, cardiovascular events, and infections.
- Effective management necessitates a deep understanding of immunosuppressive therapies and their toxicity profiles.
Purpose:
- To provide a comprehensive overview of immunosuppressants used in managing glomerular diseases.
- To highlight the less frequently used agents, rituximab and cyclophosphamide, and their associated toxicities.
- To offer practical guidance on preventing thromboembolism in nephrotic states and Pneumocystis jirovecii pneumonia.
Summary:
- Discusses the extrarenal manifestations of glomerular diseases, emphasizing infections and thromboembolism.
- Reviews common immunosuppressants (calcineurin inhibitors, antimetabolites) and details rituximab and cyclophosphamide.
- Provides recommendations for thromboembolism prophylaxis in nephrosis and Pneumocystis jirovecii pneumonia prophylaxis.
Impact:
- Enhances clinical decision-making regarding immunosuppressive therapy in glomerular diseases.
- Improves patient outcomes by addressing critical extrarenal complications and optimizing prophylaxis strategies.
- Contributes to the evidence base for managing complex glomerular diseases and their associated risks.
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