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Prolactinoma and adrenal androgens.
The Journal of Reproductive Medicine
|August 1, 1986
Summary
Hyperprolactinemia modifies steroid pathways, impacting 3beta-hydroxysteroid dehydrogenase (3beta-OHSD) activity. Post-surgery, androgen levels decreased, suggesting other factors influence adrenal androgens beyond prolactin.
Area of Science:
- Endocrinology
- Reproductive Medicine
- Biochemistry
Background:
- Conflicting theories exist regarding hyperprolactinemia and hyperandrogenism.
- Prolactin's influence on delta 5 and delta 4 steroid pathways via 3beta-hydroxysteroid dehydrogenase (3beta-OHSD) is debated.
Purpose of the Study:
- To investigate the relationship between hyperprolactinemia and androgen production.
- To determine the effect of prolactinomas on delta 5 and delta 4 steroid levels.
- To explore the role of 3beta-OHSD in hyperprolactinemic women.
Main Methods:
- Measurement of delta 5 and delta 4 steroids, prolactin, and cortisol in 18 hyperprolactinemic women pre- and post-prolactinoma resection.
- Comparison with a control group of five women.
- Analysis of individual delta 5: delta 4 steroid ratios.
Main Results:
- Significant differences in preoperative and postoperative steroid levels were observed in hyperprolactinemic women.
- Results support the modification of delta 5, delta 4 pathways by affecting the rate-limiting enzyme 3beta-OHSD.
- Adrenal androgens decreased post-surgery, independent of prolactin levels.
Conclusions:
- Hyperprolactinemia impacts steroidogenesis, likely through modulation of 3beta-OHSD.
- Factors other than ACTH and prolactin may modulate adrenal androgens in hyperprolactinemic states.