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Accelerated Bone Regeneration on the Metal Surface through Controllable Surface Potential.

Weiming Lin¹, Zhiyuan Zhou¹, Zhuoneng Chen²

¹School of Materials Science and Engineering, Center of Rehabilitation Biomedical Materials, Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou 310027, Peoples R China.

ACS Applied Materials & Interfaces

|September 20, 2023

Summary

Controlling surface potential on titanium (Ti) surfaces using poled poly(vinylidene fluoride-trifluoroethylene) (PVTF) significantly enhances bone regeneration. This method promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by modulating intracellular calcium ion levels.

Keywords:

BMSCs bone regeneration metal surface osteogenic differentiation surface potential

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Area of Science:

Biomaterials Science
Regenerative Medicine
Surface Chemistry

Background:

Surface potential is an understudied factor in metal-based tissue regeneration.
Titanium (Ti) is a common biomaterial for implants, but its bioactivity can be further enhanced.
Understanding surface properties is crucial for developing advanced medical devices.

Purpose of the Study:

To investigate the independent effect of tailored surface potential on titanium for tissue regeneration.
To explore the mechanism by which surface potential influences cell behavior and bone formation.
To assess the potential of adjustable surface potential for implantable medical devices.

Main Methods:

Designed and fabricated Ti surfaces with adjustable surface potential using ferroelectric and piezoelectric poly(vinylidene fluoride-trifluoroethylene) (PVTF).
Cultured bone marrow mesenchymal stem cells (BMSCs) on modified Ti surfaces in vitro.
Evaluated osteogenic differentiation of BMSCs and bone regeneration in vivo.
Measured intracellular calcium ion (Ca2+) concentration to elucidate the underlying mechanism.

Main Results:

Tailored surface potential on Ti surfaces significantly promoted osteogenic differentiation of BMSCs in vitro.
Enhanced bone regeneration was observed in vivo with the modified Ti surfaces.
Surface potential was shown to activate transmembrane calcium channels, increasing intracellular Ca2+ concentration.
The influx of extracellular Ca2+ into the cytoplasm is proposed as the mechanism for improved osteogenesis.

Conclusions:

Adjustable surface potential on metal surfaces is a viable strategy to enhance bioactivity and stimulate osteogenesis.
This approach holds significant promise for the development of next-generation implantable medical devices.
The findings highlight the importance of surface potential in biomaterial design for regenerative medicine.