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Longitudinal relationships between depressive symptoms and cognitive function after stroke: A cross-lagged panel

Wenwen Liang1, Jinfeng Miao1, Yanyan Wang1

  • 1Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

Journal of Psychosomatic Research
|September 20, 2023
PubMed

Insights

Post-stroke depressive symptoms and cognitive impairment have a bidirectional, causal relationship. Addressing depression may improve cognitive function, and vice versa, in stroke survivors.

Area of Science:

  • Neurology
  • Psychiatry
  • Rehabilitation Medicine

Background:

  • Stroke is a primary cause of death and disability globally.
  • Post-stroke depressive symptoms and cognitive impairment are common, yet their relationship is not fully understood.
  • Understanding this relationship is crucial for improving stroke patient outcomes.

Purpose of the Study:

  • To investigate the temporal and directional relationship between depressive symptoms and cognitive impairment after ischemic stroke.
  • To elucidate the causal link between these two common post-stroke complications.
  • To inform clinical interventions for better stroke prognosis.

Main Methods:

  • A multicenter prospective cohort study involving 610 ischemic stroke patients.
  • Assessment of depressive symptoms (Hamilton Rating Scale for Depression) and cognitive function (Montreal Cognitive Assessment) at baseline and 12-month follow-up.
  • Cross-lagged panel analysis to determine the causal relationship, adjusting for covariates.

Main Results:

  • A significant bidirectional relationship was found between depressive symptoms and cognitive function over time.
  • Early depressive symptoms predicted later cognitive impairment.
  • Higher baseline cognitive function predicted fewer depressive symptoms at follow-up.

Conclusions:

  • A reciprocal causal relationship exists between depressive symptoms and cognitive function post-ischemic stroke.
  • Interventions targeting either depression or cognitive function may have beneficial effects on both domains.
  • This finding highlights the importance of integrated care for stroke survivors.
Abstract

Keywords:
Cognitive functionCross-lagged panel designDepressive symptomsStrokeTemporal relationship

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