Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

652
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
652
Nociception01:44

Nociception

28.0K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
28.0K
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

864
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
864
Pain01:20

Pain

501
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
501

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Failure rate and treatment plan options of dental implants in patients with fibro-osseous lesions: a systematic review.

Maxillofacial plastic and reconstructive surgery·2026
Same author

Artificial Intelligence Applications in Cleft Lip and Palate Diagnosis, Prediction, and Treatment: A Systematic Review and Meta-Analysis.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
Same author

The Impact of Small Molecule on the Astrocyte's Viability Derived From Epileptic Brain Tissues.

Basic and clinical neuroscience·2026
Same author

Chrysin against Endocrine and Reproductive Systems Impairment: Current Evidence and Future Perspectives.

Current medicinal chemistry·2026
Same author

Corrigendum to "Long non-coding RNAs and exosomal lncRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling" [Biomed. Pharmacother. 150 (2022) 112963].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Glymphatic System Dysfunction in Alzheimer's Disease: Insights into its Mechanisms, Diagnostic Imaging, and Therapeutic Perspectives: A Systematic Review.

Current Alzheimer research·2026

Related Experiment Video

Updated: Jul 16, 2025

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
08:16

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Published on: October 6, 2022

6.4K

miRNA contributes to neuropathic pains.

Reyhaneh Vali1, Ali Azadi2, Ashkan Tizno3

  • 1Department of Biology, Faculty of Modern Science, Tehran Medical Branch, Islamic Azad University, Tehran, Iran; Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.

International Journal of Biological Macromolecules
|September 20, 2023
PubMed
Summary

microRNAs (miRNAs) are key regulators in neuropathic pain (NP). Targeting these small molecules offers a promising therapeutic strategy for chronic pain and prevention of NP.

Keywords:
Chronic painInflammationMicroRNANPNeuralgiaNeuropathy

More Related Videos

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

48.3K
Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice
04:34

Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice

Published on: January 25, 2022

4.9K

Related Experiment Videos

Last Updated: Jul 16, 2025

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
08:16

Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies

Published on: October 6, 2022

6.4K
The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Published on: July 16, 2014

48.3K
Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice
04:34

Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice

Published on: January 25, 2022

4.9K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Neuropathic pain (NP) arises from nervous system injury.
  • microRNAs (miRNAs) are small noncoding RNAs regulating gene expression.
  • NP involves altered expression of receptors and mediators, potentially influenced by miRNAs.

Purpose of the Study:

  • To elucidate the intricate relationship between neuropathic pain and miRNAs.
  • To bridge the fields of neurology, biology, and dentistry concerning NP.
  • To explore miRNAs as therapeutic targets for NP.

Main Methods:

  • This study is a comprehensive review of existing literature.
  • Analysis of research on miRNA involvement in NP pathogenesis.
  • Examination of potential therapeutic applications of miRNA modulation.

Main Results:

  • miRNAs play a significant role in the molecular mechanisms underlying NP.
  • Evidence suggests miRNAs contribute to altered gene expression in NP.
  • miRNA dysregulation is implicated in the development and maintenance of NP.

Conclusions:

  • Targeting miRNAs presents a viable therapeutic avenue for managing chronic pain.
  • miRNA-based interventions may offer novel strategies for NP prevention.
  • Further research into miRNA modulation holds promise for NP treatment across disciplines.