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Updated: Jul 16, 2025

Systematic Analysis of In Vitro Cell Rolling Using a Multi-well Plate Microfluidic System
Published on: October 16, 2013
Microrollers flow uphill as granular media
Samuel R Wilson-Whitford1, Jinghui Gao1, Maria Chiara Roffin1,2
1Department of Chemical and Biomolecular Engineering, Lehigh University, Bethlehem, PA, 18015, USA.
Abstract:
Pour sand into a container and only the grains near the top surface move. The collective motion associated with the translational and rotational energy of the grains in a thin flowing layer is quickly dissipated as friction through multibody interactions. Alternatively, consider what will happen to a bed of particles if one applies a torque to each individual particle. In this paper, we demonstrate an experimental system where torque is applied at the constituent level through a rotating magnetic field in a dense bed of microrollers. The net result is the grains roll uphill, forming a heap with a negative angle of repose. Two different regimes have been identified related to the degree of mobility or fluidisation of the particles in the bulk. Velocimetry of the near surface flowing layer reveals the collective motion of these responsive particles scales in a similar way to flowing bulk granular flows. A simple granular model that includes cohesion accurately predicts the apparent negative coefficient of friction. In contrast to the response of active or responsive particles that mimic thermodynamic principles, this system results in macroscopic collective behavior that has the kinematics of a purely dissipative granular system.
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