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Updated: Jul 16, 2025

Assessment of the Acute Inhalation Toxicity of Airborne Particles by Exposing Cultivated Human Lung Cells at the Air-Liquid Interface
Published on: February 23, 2020
Evaluation of face shields used during aerosol generating procedures
Alessandra A Pratt1,2, Grant D Brown3, Jarrett E Walsh4
1Department of Occupational and Environmental Health, University of Iowa, 145 N Riverside Dr., Iowa City, IA, 52242, USA. Alessandra.Pratt@va.gov.
A new negative pressure face shield (NPFS) effectively reduced virus aerosols during simulated laryngoscopy. Standard face shields offered no significant aerosol protection, highlighting NPFS benefits for infection control.
Area of Science:
- Medical Devices
- Infectious Disease Control
- Respiratory Medicine
Background:
- Transnasal flexible laryngoscopy is an aerosol-generating procedure, posing infection risks.
- Standard disposable plastic face shields may not adequately contain patient-generated aerosols.
- A novel negative pressure face shield (NPFS) was developed to mitigate aerosol spread during laryngoscopy.
Purpose of the Study:
- To evaluate the efficacy of the NPFS in controlling virus aerosols compared to a standard plastic face shield.
- To assess aerosol reduction across various particle sizes.
Main Methods:
- Utilized a simulated patient coughing machine to aerosolize MS2 bacteriophage as a SARS-CoV-2 surrogate.
- Tested both a standard plastic face shield and an NPFS under simulated coughing conditions.
- Measured virus and particle concentrations inside and outside the face shields at different NPFS flow rates (38.6 LPM and 10 LPM).
Main Results:
- The standard face shield showed no significant difference in virus aerosol concentration inside versus outside.
- The NPFS significantly decreased virus and particle concentrations outside when operated at 38.6 LPM (p < 0.01).
- At 10 LPM, the NPFS did not significantly reduce virus concentrations but did reduce particle counts (p < 0.05).
Conclusions:
- The NPFS demonstrates significant potential for reducing virus aerosol transmission during flexible laryngoscopy.
- Optimal performance of the NPFS for aerosol control is flow rate-dependent.
- Further research may validate NPFS effectiveness in clinical settings for enhanced patient and healthcare worker safety.
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