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Updated: Jul 16, 2025

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

10.5K

Oestrogen receptor-independent actions of oestrogen in cancer

Prarthana Gopinath1, Revathi Paramasivam Oviya2, Gopal Gopisetty3

  • 1Department of Molecular Oncology, Cancer Institute (WIA), Adyar, Chennai, 600020, India.

Molecular Biology Reports
|September 21, 2023
PubMed

Insights

Oestrogen

Area of Science:

  • Endocrinology and Cancer Biology

Background:

  • Oestrogen is a key hormone in tumourigenesis, primarily acting via oestrogen receptors (ERα/β).
  • Estrogen receptor-positive (ER+) breast cancers, representing ~70% of cases, are treated with endocrine therapies like tamoxifen.

Purpose of the Study:

  • To review non-classical oestrogen signalling pathways.
  • To explore the role of ER-independent oestrogen actions in cancer.
  • To discuss the clinical significance of these alternative pathways.

Main Methods:

  • Literature review of non-classical oestrogen signalling.
  • Analysis of ER-independent pathways in cancer development.
  • Examination of clinical implications and drug targets.

Main Results:

  • Tamoxifen resistance occurs in up to 25% of patients, potentially due to ER-independent oestrogen actions.
  • ER-independent signalling involves membrane receptors, oxidative metabolism, mitochondria, and inflammatory cytokines.
  • These pathways offer new therapeutic targets beyond classical ER signalling.

Conclusions:

  • ER-independent oestrogen signalling is crucial in cancer, particularly in tamoxifen resistance.
  • Understanding these non-classical pathways expands therapeutic strategies for ER+ breast cancer.
  • Targeting ER-independent oestrogen actions may overcome endocrine therapy resistance.
Keywords:
Breast cancerEstrogen metabolitesEstrogen receptor-independent signallingGPER1Tamoxifen resistance

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