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Author Spotlight: Advancing Tendon Tissue Engineering with 3D Organoid Models

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Cell Sheet Technology: An Emerging Approach for Tendon and Ligament Tissue Engineering.

Yexin Li¹, Ting Deng¹, Dilihumaer Aili²

¹Department of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, People's Republic of China.

Annals of Biomedical Engineering

|September 21, 2023

Summary

Cell sheet technology offers a promising approach for regenerating tendon and ligament tissues, addressing their limited healing capacity. This review explores its preclinical success in promoting healing and reducing inflammation for musculoskeletal injuries.

Keywords:

Cell sheet Enthesis Ligament Regenerative medicine Tendon Tissue engineering

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Last Updated: Jul 16, 2025

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Author Spotlight: Advancements in Cell and Tissue Engineering for Tendon Repair

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Published on: March 1, 2024

Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells

Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells

Published on: August 1, 2020

Area of Science:

Regenerative Medicine
Biomaterials Science
Musculoskeletal Research

Background:

Tendon and ligament injuries are common musculoskeletal disorders with limited natural regenerative capacity.
Current treatments face challenges in fully restoring native tissue structure and function.
Cell sheet technology presents an innovative strategy for tissue engineering and regenerative medicine.

Purpose of the Study:

To review the application of cell sheet technology in treating tendon and ligament injuries.
To summarize advancements in stem cell-derived sheets for musculoskeletal tissue regeneration.
To discuss challenges and future directions for clinical translation.

Main Methods:

Review of preclinical studies on cell sheet technology for tendon and ligament repair.
Summary of cell sheet harvesting procedures and their advantages.
Analysis of stem cell-derived sheets' effects on inflammation and healing.

Main Results:

Cell sheet technology preserves cell-to-cell connections and extracellular matrix, crucial for tissue regeneration.
Preclinical studies demonstrate efficacy of stem cell-derived sheets in mitigating inflammation and enhancing tendon/graft-bone healing.
Successful application in animal models for tendon and ligament injury repair.

Conclusions:

Cell sheet technology shows significant potential for treating tendon and ligament injuries.
Future clinical translation requires optimized cell sources, preparation processes, and animal models.
Development of vascularized complex tissues using cell sheet technology is essential for clinical success.