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Updated: Jul 16, 2025

Assays for the Degradation of Misfolded Proteins in Cells
Published on: August 28, 2016
Protein quality control: from molecular mechanisms to therapeutic intervention-EMBO workshop, May 21-26 2023,
Christian Münch1, Janine Kirstein2,3
1Institute of Biochemistry II, Medical Faculty, Goethe University Frankfurt, Frankfurt am Main, Germany.
Abstract:
Protein quality control pathways ensure a functional proteome and rely on a complex proteostasis network (PN) that is composed of molecular chaperones and proteases. Failures in the PN can lead to a broad spectrum of diseases, including neurodegenerative disorders like Alzheimer's, Parkinson's, and a range of motor neuron diseases. The EMBO workshop "Protein quality control: from molecular mechanisms to therapeutic intervention" covered all aspects of protein quality control from underlying molecular mechanisms of chaperones and proteases to stress signaling pathways and medical implications. This report summarizes the workshop and highlights selected presentations.
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