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Updated: Jul 16, 2025

Assessment of Submitochondrial Protein Localization in Budding Yeast Saccharomyces cerevisiae
Published on: July 19, 2021
Mitochondrial protein and organelle quality control-Lessons from budding yeast
Emily Jie-Ning Yang1, Pin-Chao Liao2, Liza Pon1
1Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA.
Abstract:
Mitochondria are essential for normal cellular function and have emerged as key aging determinants. Indeed, defects in mitochondrial function have been linked to cardiovascular, skeletal muscle and neurodegenerative diseases, premature aging, and age-linked diseases. Here, we describe mechanisms for mitochondrial protein and organelle quality control. These surveillance mechanisms mediate repair or degradation of damaged or mistargeted mitochondrial proteins, segregate mitochondria based on their functional state during asymmetric cell division, and modulate cellular fitness, the response to stress, and lifespan control in yeast and other eukaryotes.
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