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T/myeloid mixed-phenotype acute leukemia treated with venetoclax and decitabine: A case report

Sungwoo Park1, Eun Jeong Jeong1, Jung Hun Kang1

  • 1Division of Hematology and Oncology, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Gyeongsang National University, Jinju 52727, South Korea.

World Journal of Clinical Cases
|September 21, 2023
PubMed
Abstract

Insights

This case study highlights a novel treatment approach for mixed-phenotype acute leukemia (MPAL). A patient achieved complete remission using venetoclax and decitabine followed by haploidentical stem cell transplant.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Mixed-phenotype acute leukemia (MPAL) presents a diagnostic challenge due to co-expression of myeloid and lymphoid antigens.
  • The rarity of MPAL hinders the establishment of standardized treatment protocols.
  • Optimal management strategies for MPAL remain under investigation.
Keywords:
Case reportDecitabineMixed-phenotype acute leukemiaVenetoclax

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