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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

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A quick algorithmic review on management of viral infectious diseases in pediatric solid organ transplant recipients

Marjan Moghadamnia1, Hamid Eshaghi2, Hosein Alimadadi3

  • 1Department of Pharmacotherapy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Frontiers in Pediatrics
|September 21, 2023
PubMed

Insights

Pediatric solid organ transplant recipients face significant risks from viral infections like CMV and EBV. This review outlines key prevention and treatment strategies to improve outcomes for these vulnerable children.

Area of Science:

  • Pediatric transplantation and infectious diseases.

Background:

  • Pediatric solid organ transplantation (SOT) is crucial for end-stage organ failure but carries risks.
  • Viral infections are a major cause of morbidity and mortality in immunosuppressed pediatric SOT recipients.
  • Common culprits include cytomegalovirus (CMV), Epstein-Barr virus (EBV), herpes simplex virus (HSV), varicella-zoster virus (VZV), adenoviruses, and BK polyomavirus.

Purpose of the Study:

  • To provide a concise overview of prevention and treatment strategies for viral infections in pediatric SOT recipients.
  • To highlight common viral pathogens and their impact on transplant outcomes.
  • To offer an algorithmic approach to managing these infections.

Main Methods:

  • Literature review focusing on viral infections in pediatric SOT.
  • Synthesis of current guidelines and evidence for prevention and treatment.
  • Development of an algorithmic overview for clinical application.

Main Results:

  • Identified key viruses posing risks: CMV, EBV, HSV, VZV, adenoviruses, BK polyomavirus.
  • Prevention strategies include pre-transplant vaccination, post-transplant prophylaxis, and preemptive therapy.
  • Treatment involves antiviral agents and potential immunosuppression modification, tailored to the specific virus.

Conclusions:

  • Effective management of viral infections is critical for successful pediatric SOT.
  • A proactive approach combining prevention, monitoring, and timely treatment is essential.
  • Algorithmic strategies can aid clinicians in navigating complex viral infection management in this population.

Keywords:
antiviralpediatricssolid organtransplantationviral infections

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