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Published on: May 10, 2022
CD39 molecule: a negative regulator expressed on T cells in patients with lung adenocarcinoma
Introduction:
The function of cytotoxic cells may be impacted by CD39 expression on CD8-positive T lymphocytes, leading to an imbalance in tumor immunity.
Methods:
We analyzed the correlation between the expression of CD39 on CD8-positive T lymphocytes and clinical information in 203 patients with lung adenocarcinoma.
Results:
The expression of CD39 on CD8-positive T lymphocytes was related to T stage, lymph node metastasis and distant metastasis. Furthermore, the CD39 expression reduced the secretion of antitumor cytokines, promoted PD-1 expression and decreased CD28 expression on CD8-positive T lymphocytes.
Conclusions:
This research demonstrated the potential value of CD39 on CD8-positive T lymphocytes as a negative regulator in cancer immunotherapy.
