Related Experiment Video
Updated: Jul 16, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Renal involvement in systemic lupus erythematosus: additional histopathological lesions
Monique Pereira Rêgo Muniz1, Laise Pereira Arcoverde Fechine Brito2, Pedro Henrique Cavalcante Vale2
1Department of Nephrology, Presidente Dutra Universitary Hospital, University of Maranhão (UFMA), São Luís, MA, Brazil.
Abstract:
A common criticism of the classification of lupus nephritis is the relative scarcity of information regarding tubular, interstitial, and vascular changes compared to the available information regarding glomerular changes, even though their potential for independent progression is known. This study reviewed the importance of less explored lesions by the current and widely used 2003 classification of lupus nephritis of the International Society of Nephrology/Renal Pathology Society (ISN/RPS), with emphasis on the tubulointerstitial, podocyte, and vascular lesions, increasingly recognised as being important in the pathogenesis and prognosis of the disease. Recognition of these lesions can help with therapeutic decision-making, thereby allowing better results for patients with systemic lupus erythematosus.
Related Concept Videos
Endocarditis II: Clinical Features of Infective Endocarditis
Nephrotic Syndrome I : Introduction
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Rheumatic Heart Disease I: Introduction
Chronic Kidney Disease II: Clinical Manifestations

