Related Experiment Video
Updated: Jul 16, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
Identification of gene polymorphisms associated with fat mass by genome-wide association study in Chinese people
Luyue Qi1,2, Zhenlin Zhang1, Weiwei Hu1
1Shanghai Clinical Research Center of Bone Diseases, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Introduction:
This study aimed to investigate the relationship of gene polymorphisms and fat mass (FM) in Chinese population.
Methods:
Healthy males, premenopausal and postmenopausal women were recruited. Single Nucleotide Polymorphisms (SNPs) and FM were measured.
Results:
The rs141206415 in the RASAL1 gene and rs144493374 in the PALLD gene were associated with trunk FM, and the rs4807023 in the PTPRS gene was associated with leg FM using Spearman correlation analysis.
Conclusions:
The results suggest that the RASAL1 gene and the PALLD gene might contribute to variability of trunk FM in healthy Chinese Han people. The PTPRS gene is potentially correlated with leg FM. Our findings provide a clue in fat metabolism.
More Related Videos
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Single Nucleotide Polymorphisms-SNPs
Polygenic Traits
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...

