Related Experiment Video

Updated: Jul 16, 2025

In Vivo Thoracic Dorsal Root Ganglia (DRG) Calcium Imaging and ECG Recording for Studying Peripheral Nerve Stimulation
06:34

In Vivo Thoracic Dorsal Root Ganglia (DRG) Calcium Imaging and ECG Recording for Studying Peripheral Nerve Stimulation

Published on: August 16, 2024

904

Membrane Lipid Nanodomains Modulate HCN Pacemaker Channels in Nociceptor DRG Neurons

Lucas J Handlin, Natalie L Macchi, Nicolas L A Dumaire

    Biorxiv : the Preprint Server for Biology
    |September 21, 2023
    PubMed

    More Related Videos

    Patch Clamp Recordings on Intact Dorsal Root Ganglia from Adult Rats12:00

    Patch Clamp Recordings on Intact Dorsal Root Ganglia from Adult Rats

    Published on: September 29, 2016

    14.4K
    A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice08:35

    A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice

    Published on: March 17, 2015

    14.9K

    Related Concept Videos

    Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

    Ligand-Gated Ion Channel Receptor: Gating Mechanism

    Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
    2.3K
    Nociception01:44

    Nociception

    Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
    28.0K
    G-Protein Gated Ion Channels01:21

    G-Protein Gated Ion Channels

    GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
    Sensory...
    4.6K
    Mechanically-gated Ion Channels01:12

    Mechanically-gated Ion Channels

    Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
    6.4K
    The Role of Ion Channels in Neuronal Computation01:19

    The Role of Ion Channels in Neuronal Computation

    A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
    Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
    3.2K
    Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

    Local Anesthetics: Differential Sensitivity of Nerve Fibers

    Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
    857