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Updated: Jul 16, 2025

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
Phenotype and genotype analysis for Helicobacter pylori antibiotic resistance in outpatients: a retrospective study
Mengqiu Xiong1, Hend Sadeq Mohammed Aljaberi1, Nida Khalid Ansari1
1Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University , Nanjing, China.
Importance:
Helicobacter pylori is a key bacterium that causes stomach diseases. There was a high prevalence of H. pylori in the Chinese population. We analyzed the resistance phenotype and genotype characteristics of H. pylori in 4,399 outpatients at the First Hospital of Nanjing, China. We found a higher resistance rate to metronidazole (MTZ) , clarithromycin (CLR), and levofloxacin (LEV), and the genotype could be used to predict the phenotypic H. pylori resistance to CLR and LEV. This study provides information on H. pylori infection and also provides guidance for clinical doctors' drug treatment.
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