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Updated: Jul 16, 2025
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Biaxial Mechanical Characterizations of Atrioventricular Heart Valves
Published on: April 9, 2019
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Multiscale structure and function of the aortic valve apparatus
Hussam El-Nashar1,2, Malak Sabry1,3, Yuan-Tsan Tseng4,5
1Aswan Heart Research Centre, Magdi Yacoub Foundation, Cairo, Egypt.
Physiological Reviews
|September 21, 2023
Summary
The aortic valve apparatus (AVA) functions as an integrated unit with surrounding structures. Understanding this complex interplay across multiple scales is key to treating AVA diseases and maintaining cardiovascular health.
Area of Science:
- Cardiovascular Physiology
- Biomedical Engineering
- Multiscale Modeling
Background:
- Isolated aortic valve study has advanced treatments.
- The aortic valve apparatus (AVA) involves dynamic interplay with surrounding structures.
- AVA is crucial for unidirectional flow, coronary perfusion, and ventricular support.
Purpose of the Study:
- To review the integrated function of the aortic valve apparatus (AVA).
- To explore multiscale phenomena underlying AVA functions.
- To discuss tools and pathologies related to AVA.
Main Methods:
- Review of medical imaging modalities.
- Overview of experimental investigation methods.
- Inclusion of computational modeling, specifically fluid-structure interaction (FSI) simulations.
Main Results:
- The AVA functions as an integrated unit.
- Coupling of the aortic valve, root, and outflow tract is vital.
- Multiscale phenomena (molecular to tissue) govern AVA function and disease.
Conclusions:
- Viewing the AVA as an integrated functional unit is essential.
- Understanding multiscale phenomena is crucial for comprehending AVA function and disease.
- Further research is needed to address unanswered questions in AVA biology and mechanics.
Keywords:
aortic rootaortic valvebiomechanicsmolecular, developmental and cellular mechanismsstructure-function relationshipsMore Related Videos
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