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Stem cell-based therapies for heart failure management: a narrative review of current evidence and future

Gbolahan Olatunji1, Emmanuel Kokori1, Ismaila Yusuf2

  • 1Department of Medicine and Surgery, University of Ilorin, Ilorin, Nigeria.

Heart Failure Reviews
|September 21, 2023
PubMed

Insights

Stem cell therapies offer a promising new avenue for treating heart failure (HF), potentially improving cardiac function and quality of life. Rigorous safety assessments and personalized approaches are crucial for future advancements in this field.

Area of Science:

  • Cardiovascular Medicine
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Heart failure (HF) affects millions globally, necessitating novel treatments beyond symptom management.
  • Current therapies for HF primarily focus on alleviating symptoms rather than addressing root causes.
  • The rising prevalence of HF demands innovative therapeutic strategies to restore cardiac function.

Purpose of the Study:

  • To review the current status of stem cell-based therapies for heart failure management.
  • To explore the mechanisms, clinical evidence, ethical considerations, and regulatory aspects of these therapies.
  • To identify future directions for enhancing the efficacy and safety of stem cell treatments for HF.

Main Methods:

  • Comprehensive literature review of stem cell-based therapies for heart failure.
  • Analysis of clinical trial data, including both positive and negative outcomes.
  • Examination of ethical considerations and regulatory hurdles in stem cell therapy development.

Main Results:

  • Stem cell therapies demonstrate potential for improving cardiac function and patient quality of life in HF.
  • Evidence suggests possible long-term benefits, but adverse events necessitate thorough safety evaluations.
  • Optimizing stem cell types, delivery, and dosage are key to enhancing therapeutic outcomes.

Conclusions:

  • Stem cell therapies represent a significant advancement in heart failure treatment, moving beyond conventional approaches.
  • Further research is needed to refine safety protocols, personalize treatments, and address ethical/regulatory challenges.
  • Expanding access and reducing costs are vital for the widespread adoption of these innovative therapies.

Keywords:
Cardiovascular diseaseClinical trialsHeart failureRegenerative medicineStem cell therapy

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