Enhanced vasopressin release upon activation of the central neural mechanism in spontaneously hypertensive rats

Monopolar electrical stimulation of the intermediate portion of the solitary nucleus in spontaneously hypertensive rats (SHRs) with cervical cordotomy and vagotomy resulted in a 1.68 times greater increase in plasma vasopressin concentration than in Wistar rats. The result implies that such an enhanced function of the central neural mechanism to release vasopressin in SHR backs up the functionally aberrant cardiovascular receptors.