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Related Experiment Videos

Behavioral hypersensitivity to apomorphine after chronic methamphetamine--intermittent vs. continuous regimen.

K Kashihara, M Sato, Y Kazahaya

    The Japanese Journal of Psychiatry and Neurology
    |March 1, 1986
    PubMed
    Summary

    Chronic intermittent methamphetamine (MAP) exposure significantly amplifies behavioral responses to apomorphine in rats compared to continuous exposure. This suggests intermittent MAP may induce greater dopaminergic system reactivity.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Chronic methamphetamine (MAP) use can alter brain function.
    • Dopaminergic pathways are crucial for behavioral responses to drugs like apomorphine.

    Purpose of the Study:

    • To investigate the impact of different chronic methamphetamine (MAP) administration methods on behavioral sensitivity to apomorphine.
    • To compare the neurochemical effects of intermittent versus continuous MAP exposure.

    Main Methods:

    • Rats received daily intermittent MAP (4 mg/kg) or continuous MAP (via osmotic pump) for 14 days.
    • A 7-day washout period preceded apomorphine challenge (0.5 mg/kg).
    • Behavioral responses to apomorphine were quantified and compared across groups.

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    Main Results:

    • Intermittent MAP treatment led to a marked augmentation in behavioral response to apomorphine.
    • Continuous MAP treatment showed less augmentation compared to intermittent MAP.
    • Both MAP groups exhibited altered responses relative to saline controls.

    Conclusions:

    • Intermittent chronic methamphetamine administration may induce greater hypersensitivity in dopaminergic systems.
    • The pattern of drug exposure significantly influences neuroadaptive changes and subsequent drug responses.