Protocol for (E)-selective semihydrogenation of alkynes using iridium-based catalyst
1Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland.
Abstract:
In this protocol, we describe highly (E)-selective alkyne semihydrogenation employing commercially available iridium complex and a bidentate phosphine ligand. We provide steps for (E)-stilbene synthesis, remaining formic acid neutralization, and determination of the (Z)/(E) ratio using gas chromatography analysis. We then detail (E)-stilbene purification using a short pad of silica and NMR analysis. The protocol is compatible with a wide range of functionalities and different types of alkynes. For complete details on the use and execution of this protocol, please refer to Kusy et al. (2022).1.
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