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Updated: Jul 16, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Selective S-Arylation of Sulfenamides with Arynes: Access to Sulfilimines
Yifeng Guo1, Zhe Zhuang1, Xiaoying Feng1
1College of Chemistry, Beijing University of Chemical Technology (BUCT), Beijing 100029, China.
Abstract:
Sulfilimines, the aza analogues of sulfoxides, are of increasing interest in medicinal and agrochemical research programs. However, the development of efficient routes for their synthesis has remained relatively unexplored. In this study, we report a transition metal-free, selective S-arylation reaction between sulfenamides and arynes, enabling the facile preparation of structurally diverse sulfilimines under mild and redox-neutral conditions in good yields. The application value of our method was further demonstrated by scale-up synthesis, downstream derivatization, and robustness screen.
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