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Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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ErbB4 processing is involved in OGD/R induced neuron injury.

Aiqing Deng1, Shouyan Wang2, Jianxin Qin2

  • 1Department of Pharmacy, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, People's Republic of China.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|September 21, 2023
PubMed
Summary

ErbB4 protects the brain from oxygen-glucose deprivation/reperfusion (OGD/R) injury by reducing cell death and reactive oxygen species. This neuroprotective effect involves changes in Adrb1, Adrb2, Ldlr, and Dab2 gene expression.

Keywords:
ApoptosisCerebral ischemia/reperfusionErbB4Oxygen-glucose deprivation/reperfusionStroke

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • ErbB4 gene expression is altered following oxygen-glucose deprivation/reperfusion (OGD/R) brain injury.
  • The precise function and underlying mechanisms of ErbB4 in cerebral ischemia remain largely uncharacterized.

Purpose of the Study:

  • To investigate the neuroprotective role of ErbB4 in OGD/R-induced brain injury.
  • To elucidate the molecular mechanisms through which ErbB4 exerts its protective effects.

Main Methods:

  • Establishment of in vitro and in vivo cerebral ischemia/reperfusion (I/R) injury models.
  • Assessment of cell viability, apoptosis, and reactive oxygen species (ROS) production using MTT, TUNEL, and DCFH-DA assays.
  • Bioinformatics analysis, RNA-Seq, quantitative RT-PCR, and western blotting to identify key genes and analyze expression levels.

Main Results:

  • ErbB4 expression was significantly reduced in cerebral I/R injury models.
  • ErbB4 expression correlated with Adrb1, Adrb2, Ldlr, and Dab2, with differential mRNA expression observed post-OGD/R.
  • Neuregulin 1 (NRG1)-mediated activation of ErbB4 enhanced cell survival, reduced apoptosis, and decreased ROS production, effects reversed by ErbB4 siRNA.

Conclusions:

  • ErbB4 exhibits significant neuroprotective effects against OGD/R injury.
  • The protective action of ErbB4 is associated with its membrane-associated fragment and modulation of Adrb1, Adrb2, Ldlr, and Dab2 expression.