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Overcoming blood-brain barrier for targeted delivery of lysosome-targeting chimeras
Qiang Cai1, Quazi T H Shubhra2
1Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Abstract:
In a recent Chem article, Liu et al.1 introduced polydopamine-based lysosome-targeting chimeras (KPLYs). In in vitro cellular models, KPLYs adeptly cross the blood-brain barrier to target and eliminate β-amyloid aggregates. They also reduce inflammation and modulate microglial activity.
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