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Long non-coding RNAs in non-small cell lung cancer: implications for preventing therapeutic resistance

Wenjuan Liu1, Bingli Zuo2, Wenting Liu3

  • 1Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong Province 250117, China.

Biochimica Et Biophysica Acta. Reviews on Cancer
|September 21, 2023
PubMed

Insights

Long noncoding RNAs (lncRNAs) show promise as biomarkers for early lung cancer detection and predicting treatment outcomes. Understanding lncRNA roles is crucial for improving non-small cell lung cancer therapy responses.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Lung cancer exhibits high mortality globally, with current treatments often failing in advanced stages due to resistance and metastasis.
  • Existing therapies for non-small cell lung cancer (NSCLC) have limited efficacy, highlighting the need for novel diagnostic and therapeutic strategies.
  • Long noncoding RNAs (lncRNAs) are increasingly recognized for their significant roles in cancer development and progression.

Purpose of the Study:

  • To review recent findings on the functions and mechanisms of lncRNAs in non-small cell lung cancer (NSCLC) therapy response.
  • To highlight the potential of lncRNAs as biomarkers for early diagnosis and prognosis in lung cancer.
  • To explore lncRNAs as potential therapeutic targets for overcoming treatment resistance in NSCLC.

Main Methods:

  • Literature review of recent studies on lncRNAs in NSCLC.
  • Analysis of lncRNA roles in cellular mechanisms related to cancer therapy.
  • Synthesis of evidence on the diagnostic and prognostic value of lncRNAs.

Main Results:

  • Substantial evidence supports the diagnostic and prognostic value of lncRNAs in lung cancer.
  • lncRNAs are implicated in various mechanisms influencing response to radiotherapy, chemotherapy, and immunotherapy.
  • Specific lncRNAs have been identified that modulate sensitivity or resistance to NSCLC treatments.

Conclusions:

  • lncRNAs represent a promising class of molecules for improving lung cancer diagnosis and treatment strategies.
  • Further research into lncRNA mechanisms can lead to the development of novel targeted therapies for NSCLC.
  • Targeting lncRNAs may enhance the efficacy of existing treatments and improve patient outcomes in non-small cell lung cancer.
Keywords:
AngiogenesisDrug resistanceImmunotherapy resistanceLong noncoding RNANon-small cell lung cancerRadioresistance

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