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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
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Global patterns and trends in Kaposi sarcoma incidence: a population-based study
Leiwen Fu1, Tian Tian1, Bingyi Wang1
1School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China.
The Lancet. Global Health
|September 21, 2023
Summary
Kaposi sarcoma, a cancer common in people with HIV, shows significant global incidence and mortality, particularly in Africa. Addressing healthcare disparities and improving HIV/AIDS care are key for prevention.
Area of Science:
- Oncology
- Epidemiology
- Public Health
Background:
- Kaposi sarcoma (KS) is a rare tumor, yet a leading cancer among individuals with HIV/AIDS.
- It presents a significant public health challenge, especially in regions with a high HIV burden.
- Understanding global patterns and trends in KS burden is crucial.
Purpose of the Study:
- To describe the global patterns and population-wide trends in Kaposi sarcoma burden.
- To analyze incidence and mortality data from 185 countries in 2020.
- To evaluate time trends and correlations with the Human Development Index (HDI).
Main Methods:
- Utilized GLOBOCAN 2020 database for 2020 incidence and mortality estimates.
- Analyzed cancer registry data (1998-2012) for incidence trends using joinpoint regression.
- Employed correlation analysis to assess the relationship between KS rates and HDI.
Main Results:
- In 2020, global age-standardized incidence rate (ASIR) was 0.39/100,000, with 34,270 cases and 15,086 deaths (ASMR 0.18/100,000).
- Africa accounted for 73.0% of incidence and 86.6% of deaths.
- Significant correlations were found between KS rates (ASIR/ASMR) and HDI; incidence increased in Türkiye and the Netherlands, while decreasing in several other regions.
Conclusions:
- Kaposi sarcoma, while rare globally, is endemic in parts of Africa.
- Addressing healthcare resource allocation disparities and enhancing HIV/AIDS care are vital for KS prevention across different HDI levels.
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