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Related Concept Videos

Pore Transport and Ion-Pair Transport01:17

Pore Transport and Ion-Pair Transport

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Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Ionic Strength: Effects on Chemical Equilibria01:19

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The addition of an inert ionic compound increases the solubility of a sparingly soluble salt. For example, adding potassium nitrate to a saturated solution of calcium sulfate significantly enhances the solubility of calcium sulfate. Le Châtelier's principle cannot predict this shift in the equilibrium. Instead, this could be explained in terms of changes in the effective concentration of the ions in solution in the presence of added inert salt.
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Passive transport is a method of drug absorption where small, lipid-soluble drugs can move across the cell membrane. This movement happens along the concentration gradient, which is a natural flow from higher to lower concentration areas. The speed at which the drug moves is directly related to its lipid–water partition coefficient. This means that the more a drug dissolves in lipids, the faster it diffuses or spreads throughout the body. It is important to note that most drugs are either...
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The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
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Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
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Related Experiment Video

Updated: Jul 16, 2025

Multifunctional, Micropipette-based Method for Incorporation And Stimulation of Bacterial Mechanosensitive Ion Channels in Droplet Interface Bilayers
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Monatomic ions influence substrate permeation across bacterial microcompartment shells.

Daniel S Trettel1, Chris Neale2, Mingfei Zhao2

  • 1Biosciences Division, Microbial and Biome Sciences Group, Los Alamos National Laboratory, Los Alamos, NM, USA.

Scientific Reports
|September 21, 2023
PubMed
Summary
This summary is machine-generated.

Ions like chloride can block pores in bacterial microcompartments (BMCs), hindering their function. Understanding this ion interaction is key to improving BMCs for biomanufacturing applications.

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Area of Science:

  • Biochemistry
  • Structural Biology
  • Biotechnology

Background:

  • Bacterial microcompartments (BMCs) are protein-based organelles with selectively permeable shells, offering potential for biomanufacturing.
  • BMC shell permeability is crucial for their function and can be modulated by pore properties.

Purpose of the Study:

  • To investigate the influence of ion concentration on BMC shell permeability.
  • To elucidate the mechanism by which ions interact with BMC shell pores.

Main Methods:

  • In vitro activity assays comparing native and disrupted BMCs under varying NaCl concentrations.
  • Molecular dynamics simulations of the primary BMC shell protein (BMC-H) to analyze ion-pore interactions.

Main Results:

  • Increased NaCl concentration was found to reduce substrate permeation rates through BMC shells.
  • Molecular dynamics simulations showed chloride ions accumulating in positively charged pores, obstructing substrate passage.
  • Sodium ions were observed to be excluded from these pores.

Conclusions:

  • BMC shell pore properties significantly influence ion permeability, impacting substrate transport.
  • The findings highlight how ion-BMC pore interactions can be a critical factor in BMC function.
  • This research provides insights for engineering BMCs with tailored permeability for biotechnological applications.