Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Occurrence and Exposure Assessment of Paralytic Shellfish Toxins from Shellfish in Zhejiang Province, China.

Toxins·2023
Same author

Antibacterial and hemostatic chitin sponge directly constructed from Pleurotus Eryngii via top-down approach.

International journal of biological macromolecules·2023
Same author

Dietary supplementation with honeycomb extracts positively improved egg nutritional and flavor quality, serum antioxidant and immune functions of laying ducks.

Frontiers in veterinary science·2023
Same author

Identification and Characterization of CtUGT3 as the Key Player of Astragalin Biosynthesis in <i>Carthamus tinctorius</i> L.

Journal of agricultural and food chemistry·2023
Same author

The impact of perioperative opioid use on postoperative outcomes following spinal surgery: a meta-analysis of 60 cohort studies with 13 million participants.

The spine journal : official journal of the North American Spine Society·2023
Same author

[Occurrence and exposure assessment of fumonisins from grains and grain products in Zhejiang Province in 2018-2019].

Wei sheng yan jiu = Journal of hygiene research·2023

Related Experiment Video

Updated: Jul 16, 2025

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

15.8K

HU-based material conversion for BNCT accurate dose estimation.

Yi-Chiao Teng1,2, Jiang Chen1,3, Wan-Bing Zhong1

  • 1Neuboron Therapy System Ltd., Xiamen, Fujian, People's Republic of China.

Scientific Reports
|September 22, 2023
PubMed
Summary

A new Hounsfield unit-based algorithm in the NeuMANTA system refines material conversion for boron neutron capture therapy (BNCT) planning. Accurate material composition is crucial for precise dose calculation, impacting treatment outcomes and side effect assessments.

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

2.8K
Irradiator Commissioning and Dosimetry for Assessment of LQ &#945; and &#946; Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.3K

Related Experiment Videos

Last Updated: Jul 16, 2025

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

15.8K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

2.8K
Irradiator Commissioning and Dosimetry for Assessment of LQ &#945; and &#946; Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.3K

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Biomedical Engineering

Background:

  • Boron Neutron Capture Therapy (BNCT) is an advanced radiation therapy.
  • Accurate dose calculation in BNCT is critical for treatment efficacy and patient safety.
  • Treatment planning systems (TPS) require precise material characterization for dose estimation.

Purpose of the Study:

  • To introduce and evaluate a Hounsfield unit (HU)-based material conversion algorithm in the NeuMANTA BNCT TPS.
  • To assess the impact of material composition variations on dose distribution in BNCT.
  • To highlight the importance of accurate material assignment for normal tissue and tumor dose calculations.

Main Methods:

  • Development of a novel HU-based material conversion algorithm within the NeuMANTA system.
  • Refinement of HU value ranges into 96 specific groups corresponding to tissue information.
  • Analysis of dose distribution differences based on varying material compositions derived from HU values.

Main Results:

  • The HU-based algorithm allows NeuMANTA to convert regions of interest into multiple material compositions.
  • Material composition differences can alter normal tissue maximum dose rates by over 10% (biologically equivalent dose) and up to 6% (physically absorbed dose).
  • Tumor dose and neutron scattering/moderation are also significantly affected by material composition variations.

Conclusions:

  • Accurate material composition is essential for precise dose estimation in BNCT.
  • The NeuMANTA system's HU-based algorithm improves the accuracy of material assignment in BNCT treatment planning.
  • Precise dose assessment is vital for evaluating normal tissue side effects and predicting tumor control probability in BNCT.