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Erratum: Publisher's Note: "Magnetic force-based cell manipulation for in vitro tissue engineering" [APL Bioeng. <b>7</b>, 031504 (2023)].

APL bioengineering·2023

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Magnetic force-based cell manipulation for in vitro tissue engineering.

Huiqian Hu1, L Krishaa1, Eliza Li Shan Fong

  • 1Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.

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|September 22, 2023
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Summary
This summary is machine-generated.

Magnetic force-based cell manipulation offers a simpler, scaffold-free alternative for creating 3D tissue constructs. This method, using positive or negative magnetophoresis, shows promise for advancing tissue engineering applications.

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Area of Science:

  • Biotechnology
  • Tissue Engineering
  • Biomaterials

Background:

  • 3D bioprinting and microfluidics are established methods for in vitro tissue reconstruction.
  • These techniques can be complex and may impact cell viability.
  • Magnetic force-based cell manipulation presents a simpler, label-free alternative.

Purpose of the Study:

  • To review magnetic force-based cell manipulation techniques for in vitro tissue engineering.
  • To compare magnetic methods with existing 3D bioprinting and microfluidics approaches.
  • To highlight recent advancements and future challenges in magnetic cell assembly.

Main Methods:

  • Discussion of positive magnetophoresis using magnetic nanoparticles (MNPs) for cell positioning.
  • Explanation of negative magnetophoresis utilizing paramagnetic environments to manipulate cells without MNPs.
  • Overview of established 3D bioprinting and microfluidics platforms for cell assembly.

Main Results:

  • Magnetic manipulation is scaffold- and label-free, minimally affecting cell viability.
  • Both positive and negative magnetophoresis enable controlled cell assembly into 3D constructs.
  • Recent research demonstrates the application of magnetic forces in tissue engineering.

Conclusions:

  • Magnetic force-based cell manipulation is a promising technology for in vitro tissue engineering.
  • Further research is needed to overcome challenges and mature the technology for clinical applications.
  • This method offers a simplified and efficient approach to creating complex 3D tissue structures.