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Digestive Tolerance and Safety of an Anti-Regurgitation Formula Containing Locust Bean Gum, Prebiotics and
Marc Bellaiche1, Patrick Tounian2, Raish Oozeer3
1Department of Gastroenterology and Pediatric Nutrition, Hospital Robert-Debré, AP-HP, Paris, France.
Insights
This study found that an anti-regurgitation formula with locust bean gum (LBG), prebiotics, and postbiotics effectively reduced infant regurgitation and gastrointestinal discomfort. The formula was well-tolerated and improved infant well-being and parental satisfaction.
Area of Science:
- Pediatrics
- Gastroenterology
- Infant Nutrition
Background:
- Infant regurgitation significantly impacts infant and family quality of life.
- Associated functional gastrointestinal disorders require effective management strategies.
Purpose of the Study:
- To evaluate the safety, tolerance, and effectiveness of an anti-regurgitation formula.
- The formula contains locust bean gum (LBG), prebiotics, and postbiotics.
- To alleviate digestive symptoms beyond regurgitation in infants.
Main Methods:
- A 3-month study involving 190 infants with regurgitation.
- Outcomes included stool consistency/frequency, colic, constipation, diarrhea, and regurgitation severity.
- Infant crying, parental well-being, and satisfaction were also assessed.
Main Results:
- Stool characteristics remained physiological; constipation and colic significantly decreased.
- Regurgitation severity and infant crying were reduced.
- Parental satisfaction with stool consistency, formula, infant well-being, and sleep quality increased.
Conclusions:
- Formulas with LBG, prebiotics, and postbiotics are well-tolerated.
- This approach is an effective strategy for managing infant regurgitation.
- It also helps alleviate associated gastrointestinal discomfort.
Purpose:
Infant regurgitation is associated with other functional gastrointestinal disorders and signs and symptoms that have a major impact on the quality of life of infants and their families. This study evaluated the safety, tolerance, and real-world effectiveness of an anti-regurgitation formula containing locust bean gum (LBG), prebiotics, and postbiotics to alleviate digestive symptoms beyond regurgitation.
Methods:
This 3-month study involved infants with regurgitation requiring the prescription of an anti-regurgitation formula according to usual clinical practice. Outcomes included evaluation of the evolution of stool consistency and frequency; occurrence of colic, constipation, and diarrhea; and assessment of regurgitation severity. Infant crying, parental assessment of infant well-being, and parental satisfaction with the stool consistency were also evaluated.
Results:
In total, 190 infants (average age: 1.9±1.1 months) were included. After three months, stool frequency and consistency remained within the normal physiological range, with 82.7% of infants passing one or two stools per day and 90.4% passing loose or formed stools. There was no significant increase in the number of infants with diarrhea, whereas a decrease was observed in the number of infants with constipation after 1 month (p=0.001) and with colic after both 1 and 3 months (p<0.001). Regurgitation severity and crying decreased and parental satisfaction with stool consistency, formula acceptability, infant well-being, and sleep quality increased. Monitoring of adverse events did not reveal any safety concerns.
Conclusion:
Formulas containing LBG, prebiotics, and postbiotics were well tolerated and provided an effective strategy for managing infant regurgitation and gastrointestinal discomfort.
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