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A Complicated Case of Aspirin-Exacerbated Respiratory Disease With Kounis Syndrome
Krista M Shaw1, Brittanie I Neaves2, Hayden A Springer1
1Internal Medicine, Keesler Medical Center, Biloxi, USA.
Abstract:
Kounis syndrome is angina or acute coronary syndrome caused by mast cell degranulation and inflammatory cell activation. We present a case of a patient with underlying aspirin-exacerbated respiratory disease (AERD) and previous anaphylaxis to aspirin. The patient underwent aspirin desensitization and was then treated with high-dose aspirin. Unfortunately, he developed recurrent angina and myocardial infarction (MI). Numerous left heart catheterizations revealed vasospasms as the etiology of his MIs; however, therapy with increasing doses of vasodilators yielded no improvement in the patient's condition. Ultimately the patient's aspirin was discontinued and he had no recurrence of angina or MI.
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