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Altered auditory processes pattern predicts cognitive decline in older adults: different modalities with aging.
Junjie Yang1, Xiaochen Tang1, Shaohui Lin1
1Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in Aging Neuroscience
|September 22, 2023
Summary
Older adults with altered auditory mismatch negativity (MMN) show cognitive decline. This electrophysiological measure offers a promising screening tool for identifying individuals at risk of age-related cognitive impairment.
Area of Science:
- Neuroscience
- Gerontology
- Cognitive Psychology
Background:
- Hearing impairment in older adults is linked to increased dementia risk.
- Auditory processing deficits may precede cognitive decline.
- Mismatch negativity (MMN) offers insights into central auditory processing.
Purpose of the Study:
- To investigate if compromised MMN indexes predict cognitive decline in older adults.
- To explore MMN as an electrophysiological marker for cognitive impairment.
Main Methods:
- 108 community-dwelling older adults underwent cognitive testing (RBANS) and EEG.
- Auditory mismatch negativity (MMN) was measured using an auditory oddball paradigm.
- Assessments were conducted at baseline and 12-month follow-up.
Main Results:
- Cognitive decline was associated with decreased MMN peak amplitude and forward-shifted latency in young-old adults.
- Older adults showed delayed MMN latency without amplitude changes.
- MMN peak amplitude decreased with age, particularly in the 70-80 year range.
Conclusions:
- Altered MMN patterns are observed across aging stages and predict cognitive decline.
- MMN is a potential electrophysiological predictor for cognitive impairment in older adults.
- Further research is needed on MMN's neural mechanisms and implications in aging.
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