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Updated: Jul 16, 2025

Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples
Published on: June 9, 2016
Harmonic dependence of thermal magnetic particle imaging
Thinh Q Bui1, Mark-Alexander Henn2,3, Weston L Tew2
1National Institute of Standards and Technology, Gaithersburg, MD, 20895, USA. thinh.bui@nist.gov.
Abstract:
Advances in instrumentation and tracer materials are still required to enable sensitive, accurate, and localized in situ 3D temperature monitoring by magnetic particle imaging (MPI). We have developed a high-resolution magnetic particle imaging instrument and implemented a low-noise multi-harmonic lock-in detection method to observe and quantify temperature variations in iron oxide nanoparticle tracers using the harmonic ratio method for determining temperature. Using isolated harmonics for MPI and temperature imaging revealed an apparent dependence of imaging resolution on harmonic number. Thus, we present experimental and simulation studies to quantify the imaging resolution dependence on temperature and harmonic number, and directly validate the fundamental origin of MPI imaging resolution on harmonic number based on the concept of a harmonic point-spread-function.
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