Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Additional Routes of Drug Administration01:18

Additional Routes of Drug Administration

2.8K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
2.8K
Inhaled Medications01:23

Inhaled Medications

302
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
302
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

371
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
371
Breathing01:05

Breathing

59.5K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
59.5K
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

149
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
149
Ventilatory Modes01:14

Ventilatory Modes

196
Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
196

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surfactant administration via supraglottic airway in premature infants (SALSA): a survey-based assessment of current procedural practice.

Archives of disease in childhood. Fetal and neonatal edition·2026
Same author

A model for global health education through the Ethiopian newborn quality improvement ECHO initiative.

Journal of perinatology : official journal of the California Perinatal Association·2025
Same author

Prophylactic surfactant therapy in the era of less invasive surfactant delivery.

Journal of perinatology : official journal of the California Perinatal Association·2025
Same author

Prospective Evaluation of Pulse Oximetry Screening for Critical Congenital Heart Disease in a Jordanian Tertiary Hospital: High Incidence and Early Detection Challenges.

Pediatric reports·2025
Same author

High vs low CPAP strategy with aerosolized calfactant in preterm infants with respiratory distress syndrome.

Journal of perinatology : official journal of the California Perinatal Association·2024
Same author

Comparison of laryngeal mask airway and endotracheal tube placement in neonates.

Journal of perinatology : official journal of the California Perinatal Association·2023
Same journal

Assessing the real-world effects of prophylactic hydrocortisone in the Canadian Neonatal Network: A cohort study.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same journal

A comparative study of two scoring systems for the assessment of neonatal abstinence syndrome.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same journal

The fetoneonatology fellowship: a unified subspecialty for the fetal-neonatal continuum.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same journal

Short-term outcomes associated with surfactant use in respiratory distress in late preterm to early term infants.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same journal

Resuscitation of neonatal critical care: a call for identity and course correction.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same journal

Prevention and management of metabolic bone disease of prematurity: a systematic review.

Journal of perinatology : official journal of the California Perinatal Association·2026
See all related articles

Related Experiment Video

Updated: Jul 16, 2025

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease
04:21

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease

Published on: August 4, 2021

6.0K

Less invasive surfactant administration methods: Who, what and how.

S O Guthrie1, K D Roberts2

  • 1Department of Pediatrics, Division of Neonatology, Vanderbilt University School of Medicine, Nashville, TN, USA.

Journal of Perinatology : Official Journal of the California Perinatal Association
|September 22, 2023
PubMed
Summary
This summary is machine-generated.

New methods deliver surfactant without endotracheal tubes (ETT) for respiratory distress syndrome. These techniques, including thin catheter and laryngeal airway methods, offer alternatives to traditional ETT surfactant administration in neonatal intensive care units (NICUs).

More Related Videos

Intratracheal Administration of Dry Powder Formulation in Mice
07:55

Intratracheal Administration of Dry Powder Formulation in Mice

Published on: July 25, 2020

10.5K
Improved Methodology for Liquid Delivery to the Mouse Lung: Intubation using a Consumer Otoscope
13:50

Improved Methodology for Liquid Delivery to the Mouse Lung: Intubation using a Consumer Otoscope

Published on: June 17, 2025

264

Related Experiment Videos

Last Updated: Jul 16, 2025

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease
04:21

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease

Published on: August 4, 2021

6.0K
Intratracheal Administration of Dry Powder Formulation in Mice
07:55

Intratracheal Administration of Dry Powder Formulation in Mice

Published on: July 25, 2020

10.5K
Improved Methodology for Liquid Delivery to the Mouse Lung: Intubation using a Consumer Otoscope
13:50

Improved Methodology for Liquid Delivery to the Mouse Lung: Intubation using a Consumer Otoscope

Published on: June 17, 2025

264

Area of Science:

  • Neonatal Medicine
  • Respiratory Physiology
  • Medical Device Technology

Background:

  • Endotracheal tube (ETT) surfactant administration is standard for infant respiratory distress syndrome.
  • Non-invasive ventilation is increasingly used in neonatal intensive care units (NICUs).
  • This necessitates alternative surfactant delivery methods avoiding ETTs.

Purpose of the Study:

  • To review non-ETT surfactant administration techniques.
  • To discuss clinical implementation considerations for these methods.
  • To provide an overview of emerging surfactant delivery strategies.

Main Methods:

  • Literature review of surfactant administration techniques.
  • Description of minimally invasive surfactant administration (MIST) and laryngeal mask airway (LMA) methods.
  • Discussion of aerosolization and supraglottic airway (SALSA) approaches.

Main Results:

  • Several ETT-free surfactant delivery methods exist.
  • Techniques include thin catheter (LISA, MIST), aerosolization, and LMA/SALSA.
  • These methods aim to reduce invasiveness and improve outcomes.

Conclusions:

  • Non-ETT surfactant administration is evolving.
  • Clinical adoption requires careful consideration of technique and patient factors.
  • These advancements offer promising alternatives for neonatal respiratory support.