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Photoacoustic micro-viscoelastography for mapping mechanocellular properties.

Fen Yang1,2, Wei Chen1, Zhongjiang Chen3

  • 1Department of Biomedical Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Southern University of Science and Technology, Shenzhen, Guangdong, China.

Journal of Biophotonics
|September 22, 2023
PubMed
Summary

We developed photoacoustic micro-viscoelastography (PAMVE) for load-free cellular biomechanical property mapping. This technique measures local viscoelasticity in cells like macrophages and red blood cells, aiding in disease and pathophysiology studies.

Keywords:
cellular mechanicsphotoacousticviscoelasticity imaging

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Area of Science:

  • Biophysics
  • Cell Biology
  • Biomedical Engineering

Background:

  • Cellular biomechanical properties are crucial for understanding biological functions in health and disease.
  • Existing methods for measuring cell mechanics require physical contact or pre-loading, limiting their application.
  • A non-contact, load-free method is needed to accurately assess cellular mechanical properties.

Purpose of the Study:

  • To develop and validate a novel technique, photoacoustic micro-viscoelastography (PAMVE), for load-free mapping of cellular biomechanical properties.
  • To demonstrate PAMVE's capability in measuring local viscoelasticity at the micrometer scale.
  • To show PAMVE's potential in differentiating cell types based on their mechanical characteristics.

Main Methods:

  • Photoacoustic micro-viscoelastography (PAMVE) was developed, utilizing the phase characteristics of photoacoustic (PA) response.
  • The technique measures local viscoelasticity in a load-free manner at the micrometer scale.
  • PAMVE was applied to macrophages, red blood cells, adipose cells, and skeletal muscle cells.

Main Results:

  • PAMVE successfully mapped mechanocellular properties in a load-free manner.
  • Local viscoelasticity measurements were achieved on macrophages and red blood cells with micrometer precision.
  • PAMVE differentiated between adipose cells and skeletal muscle cells based on their biomechanical properties.

Conclusions:

  • PAMVE offers a novel, load-free approach for interrogating cellular biomechanical properties.
  • The technique enables precise, localized viscoelasticity measurements, advancing cellular mechanobiology.
  • PAMVE has significant potential for studying cellular mechanobiology and pathophysiology in various biological contexts.