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Updated: Jul 16, 2025
09:41
Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
Published on: March 17, 2023
2.9K
Adipose tissue lipid metabolism: lipolysis
Chung Hwan Cho1, Sanil Patel1, Prashant Rajbhandari2
1Diabetes, Obesity, and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Current Opinion in Genetics & Development
|September 22, 2023
Summary
This review details recent advances in lipolysis, the breakdown of fat. It highlights new enzymes, regulators, and pathways controlling fatty acid release from adipocytes, crucial for energy balance.
Area of Science:
- Biochemistry
- Cell Biology
- Metabolic Regulation
Background:
- White adipose tissue stores energy as triglycerides in adipocytes.
- Lipolysis is the hydrolysis of triglycerides into fatty acids, regulated by hormonal and biochemical signals.
- Decades of research have elucidated complex enzymatic and regulatory mechanisms of lipolysis.
Purpose of the Study:
- To review recent developments in enzymatic lipolytic pathways.
- To discuss the transcriptional regulation of lipolysis.
- To summarize regulators, microenvironment factors, and systemic effects of lipolysis.
Main Methods:
- Literature review focusing on the past two years of research.
- Synthesis of findings on lipolytic enzymes and coregulators.
- Analysis of transcriptional and post-transcriptional regulatory mechanisms.
Main Results:
- Discovery of novel lipolytic enzymes and associated regulatory factors.
- Characterization of signaling pathways influencing lipid hydrolysis.
- Identification of key regulators in the adipose tissue microenvironment.
Conclusions:
- Adipocyte lipolysis is a dynamic process essential for metabolic and energy homeostasis.
- Recent findings underscore the complexity of lipolysis regulation.
- Further research continues to reveal the critical role of lipolysis in overall metabolism.
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