Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

876
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
876

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-mechanistic mitochondria-mediated N-methylated YKWYYRGAA-decorated nano-chitosan conjugate carrier for treatment of NRAS-mutant-harbouring lung carcinoma.

Carbohydrate polymers·2026
Same author

Single vs Dual Lactose-Polyethylene Glycol 3000 Microcarrier Systems for Pulmonary Salmeterol and Fluticasone Targeted Delivery.

Drug design, development and therapy·2026
Same author

Topical 915-3985 MHz Microwave Sweep-Assisted Retention of Nanoemulsified α-Tocopherol for Dermatitis Treatment.

AAPS PharmSciTech·2026
Same author

Physicochemical and Biological Properties of Lyophilized Platelet-Rich Fibrin: A Scoping Review.

Tissue engineering. Part B, Reviews·2025
Same author

Tibetan medicine Pa Zhu Wan ameliorates carbon tetrachloride-induced liver fibrosis in rats by regulating the TGF-β-Smad2/3 and IL-6/JAK2/STAT3 signaling pathways.

Frontiers in pharmacology·2025
Same author

Gut-liver axis mechanisms of Hippophae rhamnoides L. in non-alcoholic fatty liver disease prevention.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2025

Related Experiment Video

Updated: Jul 16, 2025

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
12:00

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles

Published on: January 22, 2015

12.5K

Conversion of liquid chitosan-based nanoemulsions into inhalable solid microparticles: Process challenges with

Kifayatullah Shah1, Lai Wah Chan2, Tin Wui Wong3

  • 1Non-Destructive Biomedical and Pharmaceutical Research Centre, Smart Manufacturing Research Institute, Universiti Teknologi MARA Selangor, Puncak Alam, 42300, Selangor, Malaysia; Particle Design Research Group, Faculty of Pharmacy, Universiti Teknologi MARA Selangor, Puncak Alam, 42300, Selangor, Malaysia.

International Journal of Biological Macromolecules
|September 22, 2023
PubMed
Summary

Researchers developed solid nanoemulsions for anti-tubercular drugs, optimizing particle size for lung delivery. Magnesium stearate addition prevented particle growth, yielding smooth microparticles suitable for pulmonary inhalation and tuberculosis treatment.

Keywords:
ChitosanInhalationLactoseMicroparticleNanoemulsionPolysaccharide

More Related Videos

Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles
05:55

Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles

Published on: September 18, 2018

8.8K
Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications
05:26

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Published on: April 13, 2022

3.4K

Related Experiment Videos

Last Updated: Jul 16, 2025

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
12:00

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles

Published on: January 22, 2015

12.5K
Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles
05:55

Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles

Published on: September 18, 2018

8.8K
Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications
05:26

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Published on: April 13, 2022

3.4K

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Optimal lung deposition of anti-tubercular drugs requires solid particles ≤5 μm.
  • Chitosan decoration of nanoemulsions with lactose for spray drying led to oversized particles due to binding effects.

Purpose of the Study:

  • To design solid nanoemulsions with reduced particle size for improved pulmonary drug delivery.
  • To investigate additives and spray-drying parameters to mitigate chitosan binding and particle growth.

Main Methods:

  • Utilized lactose as the primary solid carrier for nanoemulsion formulation.
  • Employed magnesium stearate deposition on lactose to prevent excessive binding.
  • Optimized spray-drying variables and explored plasticization effects on constituent materials.

Main Results:

  • Magnesium stearate effectively negated chitosan-induced binding and particle growth.
  • Produced smooth-surface solid microparticles (5.45 ± 0.26 μm) with heterogeneous size distribution.
  • Achieved round particulate structures (circularity: 0.919 ± 0.002) conducive to pulmonary inhalation.

Conclusions:

  • The developed solid nanoemulsion formulation facilitates effective pulmonary drug delivery for tuberculosis treatment.
  • The strategy of using magnesium stearate and optimizing spray drying offers a viable method for producing inhalable drug particles.
  • The smooth, round microparticles enhance pulmonary deposition and therapeutic efficacy for respiratory diseases.